Challenges and Opportunities in Managing Serious Bacterial Infectionsr

Release Date: Wednesday, November 26, 2014 Expiration Date: Thursday, November 26, 2015

Educational Overview

The pandemic of multidrug-resistant (MDR) bacteria and their continuing spread is well recognized. The growing prevalence of MDR pathogens in the community and healthcare settings has challenged clinicians in maintaining a high quality of care. Of particular concern are infections caused by Gram-positive bacteria (i.e., methicillin-resistant S. aureus [MRSA], vancomycin-resistant enterococci [VRE]), Gram-negative pathogens (MDR P. aeruginosa, ESBL-producing and carbapenem-resistant Enterobacteriaceae), and Clostridium difficile. Compared to susceptible organisms, infections caused by these pathogens are associated with higher failure rates, mortality, and healthcare resource utilization. When an MDR infection is suspected, it is critical to consider multiple patient-, pathogen-, and drug-related factors in selecting an optimal therapeutic option.

This educational program utilizes a case-based approach to demonstrate how management strategies are tailored to patient and pathogen factors. Understanding how these factors can influence therapeutic selection is a critical component for successful outcomes and underscores the importance of collaboration among the various disciplines when addressing the challenges of MDR infections. The program is divided into three learning blocks that focus on 1) Gram-positive pathogens, 2) Gram-negative pathogens, and 3) C. difficile. Each block is designed to open and conclude with an interactive patient case scenario that reflects the challenges and decision-making process that occurs regularly in clinical practice when managing these difficult infections.

Target Audience

This continuing medical education activity is designed for physicians, pharmacists, and other healthcare professionals who care for patients with or at-risk of serious bacterial infections, including patients being treated for malignancy and/or with neutropenic fever.

Learning Objectives

Healthcare professionals participating in this educational activity will be able at its conclusion to:

Apply evidence-based guideline recommendations into clinical practice when managing hospitalized patients with serious bacterial infections
Identify strategies to optimize the use of available antimicrobial agents to treat multidrug-resistant bacterial infections in a pathogen-directed approach
Evaluate new and emerging therapeutic options for treating serious bacterial infections

Educational Format

These Online Presentations are based on the CME/CPE Satellite Symposium following IDWeek 2014.

Please Note: If you have received credit for attending the live symposium by the same name, you are not eligible to apply for credit for this online version.

This online activity is divided into three portable and easy to access episodes:

EPISODE 1:
Practice Case 1 Gram-Positive Infections
Optimized Approaches in Managing Gram-Positive Infections
Back to Practice Case 1
Thomas M. File, Jr., MD, MS, MACP, FIDSA, FCCP

EPISODE 2:
Practice Case 2 Gram-Negative Infections
Optimized Approaches in Managing Gram-Negative Infections
Back to Practice Case 2
Marin H. Kollef, MD, FACP, FCCP

EPISODE 3:
Practice Case 3 Clostridium difficile Infections
Optimized Approaches in Managing C. difficile Infections
Back to Practice Case
Carlene A. Muto, MD, MS

EPISODE 4:
Q&A: Open Forum
All Faculty

Faculty

	Thomas M. File, Jr. MD, MS, MACP, FIDSA, FCCP Chair, Infectious Disease Division Summa Health System Akron, OH Professor, Internal Medicine Master Teacher; Chair, Infectious Disease Section Northeast Ohio Medical University Rootstown, OH

	Carlene A. Muto, MD, MS Associate Professor of Medicine Medical Director of Infection Control and Hospital Epidemiology Center for Quality Improvement and Innovation UPMC Health System Pittsburgh, PA

	Marin H. Kollef, MD, FACP, FCCP Professor of Medicine, Division of Pulmonary and Critical Care Medicine Virginia E. & Sam J. Golman Chair in Respiratory Intensive Care Medicine Director, Critical Care Research Director, Respiratory Care Services Barnes-Jewish Hospital St. Louis, MO

ACCREDITATION
Physicians
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the Center for Independent Healthcare Education and Vemco MedEd, LLC. Center for Independent Healthcare Education (Center) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Center for Independent Healthcare Education designates this Enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Pharmacists

Center for Independent Healthcare Education is accredited by the Accreditation Council for Pharmacy Education as a provider for continuing pharmacy education. Center has assigned 2.0 contact hours (0.2 CEUs) of continuing pharmacy education credits for participating in this activity.

ACPE UAN: 0473-9999-14-010-H01-P
Activity type: Knowledge-based

For questions regarding accreditation, please contact info@jointsponsor.com

Method of Participation and Instruction for Credit

Review the entire CME/CPE information including target audience, learning objectives, and disclosures.
Review each episode.
Complete the Online Post Test, Evaluation, and Credit Application form
Please note that to receive credit you must achieve a score of at least 70%.
Physicians: Certificate of Credit will be emailed within 4 weeks of successful completion of the activity.
Pharmacists: The information that you participated will be uploaded to CPE Monitor and you will be able to access your credits from the profile you set up with NABP. For more information, please visit http://www.nabp.net/.

DISCLOSURE OF CONFLICTS ON INTEREST
In accordance with policies set forth by the Accreditation Council for Continuing Medical Education (ACCME), Center for Independent Healthcare Education requires all faculty members and spouses/significant others with an opportunity to affect the content of a continuing education activity to disclose any relevant financial relationships during the past 12 months with commercial interests. A commercial interest is any entity producing, marketing, reselling or distributing health care goods or services consumed by or used on patients. Relationships with commercial interests and conflicts of interest resulting from those relationships must be revealed to the audience and resolved prior to the activity

Relevant relationships include roles such as speaker, author, consultant, independent contractor (including research), employee, investor, advisory committee member, board member, review panelist, and investigator. If a potential speaker or author indicates a possible conflict of interest, the conflict will be resolved by choosing another speaker or author for that topical area, or the slides, handouts, and/or monograph will be reviewed and approved by a qualified commercially-disinterested peer.

Planning Committee Members
Thomas M. File, Jr., MD, MS, MACP, FIDSA, FCCP
Marin H. Kollef, MD, FACP, FCCP
Carlene A. Muto, MD, MS
Paul DeLisle
Marco Cicero, PhD
Maja Drenovac, PharmD, CCMEP

DISCLOSURE OF FINANCIAL INTEREST SUMMARY
Thomas M. File, Jr., MD (Faculty/Planner) has relevant financial relationships with commercial interests as follows:

• Advisory Board: Cubist Pharmaceuticals, Forest Laboratories, GlaxoSmithKline,
Merck & Co., Pfizer, Tetraphase

• Grant Recipient/Research Support: Pfizer, Cempra

Dr. File intends to discuss the off-label use of following: Non-approved uses of drugs for MDR pathogens.

Marin H. Kollef, MD (Faculty/Planner) has relevant financial relationships with the following commercial interests:

• Advisory Board: Cubist Pharmaceuticals and Merck & Co.

• Consultant: Cardeas, Accelerate

• Speaker’s Bureau: Cubist Pharmaceuticals and Merck & Co.

Dr. Kollef does not intend to discuss the off-label use of any products.

Carlene A. Muto, MD, MS (Faculty/Planner) does not has relevant financial relationships with commercial interests.

Dr. Muto does not intend to discuss the off-label use of any products.

Content review confirmed that the content was developed in a fair, balanced manner free from commercial bias. Disclosure of a relationship is not intended to suggest or condone commercial bias in any presentation, but it is made to provide participants with information that might be of potential importance to their evaluation of a presentation.

Fee
There is no fee to participate in this activity.

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Joint Providership
This activity is jointly provided by Center for Independent Healthcare Education and Vemco MedEd.

Commercial Support
This activity is supported by an educational grant from Cubist Pharmaceuticals.

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